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KMID : 1189420150280010001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2015 Volume.28 No. 1 p.1 ~ p.10
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The Effects of Anti-Oxidant and Phototoxic Inhibitory Activity of Rubus coreanus Fruits
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Lee In-Su
Kim Yong-Min
Kim Hee-Taek
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Abstract
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Objectives : Oxidation by active oxygen in the body, phototoxicity and photoallergic interest has grown, antioxidant and phototoxicity inhibiting substances for research progress. The purpose of this study was to examine the effects on antioxidant and phototoxicity of Rubus coreanus Fruits. Meterial and
Methods : Hs68 cell lines using the DPPH radical scavenging activity, cytotoxic, phototoxic inhibitory activity and apoptosis were measured.
Results : 1. In MTT assay, the concentrations of Rubus coreanus Fruits that were used on the test had no cytotoxicity. 2. In DPPH radical scavenging activity, the concentration of 50㎍/ml, 100㎍/ml anti-oxidant effect of Rubus coreanus Fruits was statistically significant increased than control group in dose-dependantly. 3. In phototoxic inhibitory activity, Rubus coreanus Fruits dose-dependently increased the cell viability of Hs68 cell lines. 4. The concentration of 50㎍/ml Rubus coreanus Fruits inhibited the enrichment of nucleus in the Hs68 cell stimulated with UVB.
Conclusions : These results indicate that Rubus coreanus Fruits has anti-oxidant effects and Phototoxic Inhibitory Activity. If further study is performed, the use of Rubus coreanus Fruits will be valuable and beneficial in the therapy of skin aging and damage.
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KEYWORD
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Rubus coreanus Fruits, UVB, DPPH, phototoxicity, ROS
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